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A total of 3 % of Energetic compound is excreted in urine as unchanged active compound. Tapentadol is In addition metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (two %) by CYP2D6, which can be more metabolised by conjugation. For that reason, active compound metabolism mediated by cytochrome P450 method